abrin a highly toxic ∼65 kDa glycoprotein obtained from the seeds of jequirity, or Indian liquorice (Abrus precatorius L.), a tropical Asian vine that also occurs in Florida. It consists of an ∼30 kDa acidic A chain, and an ∼35 kDa neutral B chain, held together by disulfide bonds. The A chain is a powerful
ablation 1 (in surgery) the removal or destruction of tissue by a surgical procedure. 2 (in genetics) a technique for the removal of a tissue or a particular cell type during development. It depends on the tissue-specific expression of a toxin gene such as diphtheria A (dipA) in a transgenic organism.
abl an oncogene from murine Abelson leukemia virus. The human equivalent is ABL (locus at 9q34), which encodes a tyrosine protein kinase. In humans, inappropriate activation of ABL occurs via a reciprocal translocation between chromosomes 9 and 22 in which ABL is joined at the breakpoint cluster region (bcr) of the ph1 gene on chromosome