abl an oncogene from murine Abelson leukemia virus. The human equivalent is ABL (locus at 9q34), which encodes a tyrosine protein kinase. In humans, inappropriate activation of ABL occurs via a reciprocal translocation between chromosomes 9 and 22 in which ABL is joined at the breakpoint cluster region (bcr) of the ph1 gene on chromosome 22(q11), resulting in an altered …
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